Potassium transport in Langendorff-perfused mouse hearts assessed by87Rb NMR spectroscopy
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چکیده
منابع مشابه
Optical mapping of Langendorff-perfused rat hearts.
Optical mapping of the cardiac surface with voltage-sensitive fluorescent dyes has become an important tool to investigate electrical excitation in experimental models that range in scale from cell cultures to whole-organs([1, 2]). Using state-of-the-art optical imaging systems, generation and propagation of action potentials during normal cardiac rhythm or throughout initiation and maintenance...
متن کاملRegional ischemia in hypertrophic Langendorff-perfused rat hearts.
Myocardial hypertrophy decreases the muscle mass-to-vascularization ratio, thereby changing myocardial perfusion. The effect of these changes on myocardial oxygenation in hypertrophic Langendorff-perfused rat hearts was measured using epimyocardial NADH videofluorimetry, whereby ischemic myocardium displays a high fluorescence intensity. Hypertrophic hearts, in contrast to control hearts, devel...
متن کاملIschemic postconditioning influences electron transport chain protein turnover in Langendorff-perfused rat hearts
Ischemia postconditioning (IPo) is a promising strategy in reducing myocardial ischemia reperfusion (I/R) injury (MIRI), but its specific molecular mechanism is incompletely understood. Langendorff-perfused isolated rat hearts were subjected to global I/R and received IPo in the absence or presence of the mitochondrial ATP-sensitive potassium channel (mitoKATP) blocker 5-hydroxydecanoate (5-HD)...
متن کاملVoltage-sensitive dye mapping in Langendorff-perfused rat hearts.
An imaging system suitable for recordings from Langendorff-perfused rat hearts using the voltage-sensitive dye 4-[beta-[2-(di-n-butylamino)-6-naphthyl]vinyl]pyridinium (di-4-ANEPPS) has been developed. Conduction velocity was measured under hyper- and hypokalemic conditions, as well as at physiological and reduced temperature. Elevation of extracellular [K(+)] to 9 mM from 5.9 mM caused a slowi...
متن کاملTwo-photon molecular excitation imaging of Ca transients in Langendorff-perfused mouse hearts
Rubart, Michael, Exing Wang, Kenneth W. Dunn, and Loren J. Field. Two-photon molecular excitation imaging of Ca2 transients in Langendorff-perfused mouse hearts. Am J Physiol Cell Physiol 284: C1654–C1668, 2003. First published February 12, 2003; 10.1152/ajpcell.00469. 2002.—The ability to image calcium signals at subcellular levels within the intact depolarizing heart could provide valuable in...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2005
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.20450